CIT

Across TCGA cell cohorts, CIT RNA expression is significantly associated with the go_rna of many other GO terms, with 5,070 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CIT-associated GO terms across cancer lineages are Mitotic nuclear division, Negative regulation of cell cycle phase transition, and Microtubule cytoskeleton organization involved in mitosis. Each is linked with CIT in more than 19 cancer types. Because this analysis shows association rather than direction, both CIT-to-partner and partner-to-CIT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic nuclear division grouped by CIT-low versus CIT-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CIT→partner) and Y-score (partner→CIT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Mitotic nuclear division →	+0.172	+1.342	<.001	<.001	3	20
OESOPHAGUS	Negative regulation of cell cycle phase transition →	+0.101	+1.238	<.001	<.001	3	20
SOFT_TISSUE	Microtubule cytoskeleton organization involved in mitosis →	+0.117	+1.363	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Positive regulation of mitotic cytokinesis →	+0.204	+1.649	<.001	<.001	3	20
KIDNEY	Mitotic spindle elongation →	+0.272	+1.416	<.001	<.001	3	20
BONE	Positive regulation of cell cycle →	+0.097	+1.586	.002	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,070 associations by consensus.

Mitotic nuclear division by CIT expression — OESOPHAGUS

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