CIT

Across TCGA cell cohorts, CIT mutation is significantly associated with the RNA expression of many other genes, with 2,119 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CIT-associated genes across cancer lineages are PAQR3, OR51Q1, and WDR87. Each is linked with CIT in more than 3 cancer types. Because this analysis shows association rather than direction, both CIT-to-partner and partner-to-CIT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAQR3 grouped by CIT-low versus CIT-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CIT→partner) and Y-score (partner→CIT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PAQR3 →	+0.690	+2.212	<.001	<.001	3	4
BLOOD_Leukemia	OR51Q1 →	+0.051	+2.644	<.001	.008	3	3
PANCREAS	WDR87 →	+0.025	+5.044	<.001	<.001	3	2
LARGE_INTESTINE	THOC5 →	+0.567	+3.321	.001	.002	3	2
LARGE_INTESTINE	ACBD5 →	+0.609	+1.808	.004	.001	3	2
LARGE_INTESTINE	PIGL →	+0.592	+2.584	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,119 associations by consensus.

PAQR3 by CIT expression — LARGE_INTESTINE

Explore this box plot interactively →