CISH

Across TCGA patient cohorts, CISH mutation is significantly associated with the RNA expression of many other genes, with 79 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CISH-associated genes across cancer lineages are TRIM51DP, RN7SL184P, and LINC00904. Each is linked with CISH in more than 1 cancer types. Because this analysis shows association rather than direction, both CISH-to-partner and partner-to-CISH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM51DP grouped by CISH-low versus CISH-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CISH→partner) and Y-score (partner→CISH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TRIM51DP →	+0.184	+4.215	.009	.009	3	2
SKCM	RN7SL184P →	+1.026	+4.268	<.001	.008	3	2
LIHC	LINC00904 →	+0.075	+4.720	<.001	.005	3	1
UCEC	MIR7976 →	+0.891	+3.868	<.001	.001	3	1
LIHC	NEUROG1 →	+0.036	+4.853	<.001	<.001	3	1
LIHC	OR2B8P →	+0.063	+4.589	.007	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

TRIM51DP by CISH expression — SKCM

Explore this box plot interactively →