CISH

Across TCGA cell cohorts, CISH RNA expression is significantly associated with the go_rna of many other GO terms, with 5,264 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CISH-associated GO terms across cancer lineages are Purine ribonucleoside triphosphate metabolic process, Positive regulation of endoplasmic reticulum unfolded protein response, and L-arginine biosynthetic process. Each is linked with CISH in more than 8 cancer types. Because this analysis shows association rather than direction, both CISH-to-partner and partner-to-CISH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Purine ribonucleoside triphosphate metabolic process grouped by CISH-low versus CISH-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CISH→partner) and Y-score (partner→CISH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Purine ribonucleoside triphosphate metabolic process →	+0.081	+0.686	<.001	.007	3	9
BREAST	Positive regulation of endoplasmic reticulum unfolded protein response →	+0.080	+1.768	<.001	.001	3	8
OESOPHAGUS	L-arginine biosynthetic process →	+0.250	+1.277	<.001	<.001	3	8
PANCREAS	Negative regulation of myoblast fusion →	+0.096	+0.629	<.001	.002	3	8
LARGE_INTESTINE	Fatty acid catabolic process →	+0.069	+0.784	<.001	.001	3	7
SKIN	Regulation of protein monoubiquitination →	-0.115	-0.890	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,264 associations by consensus.

Purine ribonucleoside triphosphate metabolic process by CISH expression — OVARY

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