CISD3

Across TCGA patient cohorts, CISD3 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CISD3-associated genes across cancer lineages are POM121L13P, RNU6-845P, and RN7SKP211. Each is linked with CISD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CISD3-to-partner and partner-to-CISD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POM121L13P grouped by CISD3-low versus CISD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CISD3→partner) and Y-score (partner→CISD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	POM121L13P →	+0.367	+4.538	.004	.001	3	2
UCEC	RNU6-845P →	+0.444	+4.442	<.001	.007	3	1
UCEC	RN7SKP211 →	+0.308	+3.661	.004	.009	3	1
UCEC	RNU1-100P →	+0.672	+3.911	<.001	.007	3	1
UCEC	MIR760 →	+0.895	+3.960	<.001	.007	3	1
UCEC	TRAJ21 →	+1.200	+3.936	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

POM121L13P by CISD3 expression — UCEC

Explore this box plot interactively →