CISD3

Across TCGA cell cohorts, CISD3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,865 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CISD3-associated GO terms across cancer lineages are Succinate transport, Succinate transmembrane transport, and Response to endoplasmic reticulum stress. Each is linked with CISD3 in more than 9 cancer types. Because this analysis shows association rather than direction, both CISD3-to-partner and partner-to-CISD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Succinate transport grouped by CISD3-low versus CISD3-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CISD3→partner) and Y-score (partner→CISD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Succinate transport →	+0.375	+1.438	<.001	<.001	3	10
BLOOD_Myeloma	Succinate transmembrane transport →	+0.375	+1.438	<.001	<.001	3	10
BLOOD_Myeloma	Response to endoplasmic reticulum stress →	-0.085	-0.767	<.001	.003	3	9
UPPER_AERODIGESTIVE_TRACT	DTMP biosynthetic process →	+0.185	+0.505	.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Pyrimidine deoxyribonucleoside monophosphate biosynthetic process →	+0.185	+0.505	.001	<.001	3	8
STOMACH	Aldehyde metabolic process →	+0.122	+0.872	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,865 associations by consensus.

Succinate transport by CISD3 expression — BLOOD_Myeloma

Explore this box plot interactively →