CISD2

Across TCGA cell cohorts, CISD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,151 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CISD2-associated GO terms across cancer lineages are DAMP biosynthetic process, Purine deoxyribonucleoside monophosphate biosynthetic process, and CMP biosynthetic process. Each is linked with CISD2 in more than 14 cancer types. Because this analysis shows association rather than direction, both CISD2-to-partner and partner-to-CISD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DAMP biosynthetic process grouped by CISD2-low versus CISD2-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CISD2→partner) and Y-score (partner→CISD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	DAMP biosynthetic process →	+0.168	+0.851	<.001	<.001	3	15
STOMACH	Purine deoxyribonucleoside monophosphate biosynthetic process →	+0.168	+0.851	<.001	<.001	3	15
URINARY_TRACT	CMP biosynthetic process →	+0.129	+0.761	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Attachment of spindle microtubules to kinetochore →	+0.144	+0.849	<.001	<.001	3	12
BLOOD_Lymphoma	Regulation of cell cycle checkpoint →	+0.082	+0.981	<.001	<.001	3	11
SOFT_TISSUE	Regulation of DNA damage checkpoint →	+0.082	+0.512	<.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,151 associations by consensus.

DAMP biosynthetic process by CISD2 expression — STOMACH

Explore this box plot interactively →