CIRBP

Across TCGA pan-cancer cohorts, CIRBP mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CIRBP’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where CIRBP mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CIRBP is over-expressed in tumor, although a few such as CCRCC and HNSC show the opposite, repressed pattern.

CCRCC, HNSC, and PDAC are the cancer types where CIRBP tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CIRBP mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	All	−0.451	<.001	12	view →
HNSC	Male	All	−0.499	<.001	11	view →
PDAC	Female	II,III,IV	−0.949	<.001	9	view →
LUAD	All	All	+0.147	<.001	4	view →
OV	All	All	+0.558	.029	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CIRBP–CCRCC

Open the CCRCC breakdown →