CIRBP

Across TCGA patient cohorts, CIRBP mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CIRBP-associated genes across cancer lineages are Rad50, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with CIRBP in more than 1 cancer types. Because this analysis shows association rather than direction, both CIRBP-to-partner and partner-to-CIRBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by CIRBP-low versus CIRBP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CIRBP→partner) and Y-score (partner→CIRBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.286	-3.308	.004	.009	3	2
UCEC	Caspase-7-cleavedD198 →	+1.183	+3.720	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.109	-2.301	.008	.034	3	1
UCEC	ERK2 →	+0.272	+3.700	<.001	.001	3	1
UCEC	FoxM1 →	+0.222	+3.469	.037	.002	3	1
UCEC	Heregulin →	-0.154	-1.807	.002	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Rad50 by CIRBP expression — UCEC

Explore this box plot interactively →