CIR1

Across TCGA pan-cancer cohorts, CIR1 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated CIR1 data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CIR1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CIR1 expression acts as an unfavorable survival marker.

COAD and BLCA are the cancer types where CIR1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	III,IV	0.180	0.694	.005	17	view →
BLCA	OS	Median	IV	0.183	0.598	.045	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

CIR1–COAD (OS)

Open the COAD breakdown →