CIR1

Across TCGA patient cohorts, CIR1 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,049 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible CIR1-associated proteins across cancer lineages are SEC63, PRUNE1, and PRPF31. Each is linked with CIR1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CIR1-to-partner and partner-to-CIR1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CIR1 versus SEC63 in UCEC, with a Pearson correlation of -0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CIR1→partner) and Y-score (partner→CIR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SEC63 →	-0.472	-0.304	<.001	<.001	3	4
LSCC	PRUNE1 →	+0.325	+0.271	.002	.006	3	3
PDAC	PRPF31 →	+0.186	+0.240	.005	.006	3	3
PDAC	CIR1_S202 →	+0.616	+0.293	.001	.001	3	3
PDAC	ATIC →	+0.276	+0.286	<.001	<.001	3	3
PDAC	SUMO2 →	+0.567	+0.279	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,049 associations by consensus.

CIR1 vs SEC63 — UCEC

Explore this scatter interactively →