CIR1

Across TCGA patient cohorts, CIR1 protein abundance is significantly associated with the RNA expression of many other genes, with 15,401 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CIR1-associated genes across cancer lineages are NEK2, KIF14, and HAT1. Each is linked with CIR1 in more than 4 cancer types. Because this analysis shows association rather than direction, both CIR1-to-partner and partner-to-CIR1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CIR1 versus NEK2 in UCEC, with a Pearson correlation of 0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CIR1→partner) and Y-score (partner→CIR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NEK2 →	+1.005	+0.197	.002	.007	3	5
HNSC	KIF14 →	+1.082	+0.357	<.001	<.001	3	5
LSCC	HAT1 →	+0.496	+0.256	<.001	<.001	3	5
UCEC	CDCA8 →	+1.225	+0.266	<.001	.001	3	5
HNSC	ANAPC1 →	+0.393	+0.198	<.001	<.001	3	5
UCEC	BUB1 →	+1.152	+0.242	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,401 associations by consensus.

CIR1 vs NEK2 — UCEC

Explore this scatter interactively →