CIR1

Across TCGA cell cohorts, CIR1 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CIR1-associated genes across cancer lineages are KIR2DL4, UTF1, and USP17L22. Each is linked with CIR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CIR1-to-partner and partner-to-CIR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIR2DL4 grouped by CIR1-low versus CIR1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CIR1→partner) and Y-score (partner→CIR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KIR2DL4 →	+0.167	+2.994	<.001	.006	3	2
UPPER_AERODIGESTIVE_TRACT	UTF1 →	+0.170	+4.357	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	USP17L22 →	+0.010	+4.357	<.001	.006	3	1
LUNG_NSCLC_LUAD	ACP4 →	+0.039	+3.695	<.001	.003	3	1
LUNG_NSCLC_LUAD	C8A →	+0.007	+3.564	.001	.001	3	1
LUNG_NSCLC_LUAD	COX7B2 →	+2.242	+3.847	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

KIR2DL4 by CIR1 expression — LARGE_INTESTINE

Explore this box plot interactively →