Across TCGA patient cohorts, CIPC mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CIPC-associated genes across cancer lineages are 14-3-3_beta, eEF2, and EGFR_pY1068. Each is linked with CIPC in more than 1 cancer types. Because this analysis shows association rather than direction, both CIPC-to-partner and partner-to-CIPC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CIPC→partner) and Y-score (partner→CIPC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.144	-2.973	.001	.035	3	1
UCEC	eEF2 →	+0.395	+2.321	.011	.034	3	1
UCEC	EGFR_pY1068 →	-0.283	-2.115	.009	.019	3	1
UCEC	A-Raf_pS299 →	-0.197	-3.000	<.001	.036	3	1
UCEC	Fibronectin →	-0.334	-2.115	.020	.019	3	1
UCEC	Heregulin →	-0.190	-2.308	<.001	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

CIPC survival (RNA) · tumor vs normal (RNA) · all CIPC data types