CIP2A

Across TCGA patient cohorts, CIP2A mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CIP2A-associated genes across cancer lineages are eIF4E, Caspase-7-cleavedD198, and c-Met_pY1235. Each is linked with CIP2A in more than 1 cancer types. Because this analysis shows association rather than direction, both CIP2A-to-partner and partner-to-CIP2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CIP2A-low versus CIP2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CIP2A→partner) and Y-score (partner→CIP2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.208	+2.713	.007	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.612	+2.584	.004	.010	3	2
UCEC	c-Met_pY1235 →	+0.059	+2.247	.030	.001	3	2
UCEC	14-3-3_beta →	-0.105	-2.432	.004	.018	3	1
UCEC	A-Raf_pS299 →	-0.183	-2.700	<.001	.006	3	1
UCEC	FoxM1 →	+0.226	+1.817	.017	.015	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

eIF4E by CIP2A expression — UCEC

Explore this box plot interactively →