CIP2A

Across TCGA cell cohorts, CIP2A mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CIP2A-associated genes across cancer lineages are OR10H5, DEFB136, and HIGD1C. Each is linked with CIP2A in more than 1 cancer types. Because this analysis shows association rather than direction, both CIP2A-to-partner and partner-to-CIP2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10H5 grouped by CIP2A-low versus CIP2A-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CIP2A→partner) and Y-score (partner→CIP2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR10H5 →	+0.040	+4.343	<.001	.002	3	1
LUNG_NSCLC_LUAD	DEFB136 →	+0.137	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	HIGD1C →	+0.049	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR52B4 →	+0.011	+4.078	<.001	.009	3	1
BLOOD_Leukemia	DIRAS2 →	+0.133	+4.502	<.001	.001	3	1
BLOOD_Leukemia	OR10T2 →	+0.623	+4.691	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

OR10H5 by CIP2A expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →