CINP

Across TCGA pan-cancer cohorts, CINP mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CINP data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CINP mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CINP expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, LUAD, and COAD are the cancer types where CINP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.866	0.369	.002	44	view →
LUAD	OS	Tertile	III,IV	0.244	0.839	.001	11	view →
COAD	DFS	Quartile	III,IV	0.731	1.000	.045	6	view →
LSCC	OS	Tertile	All	0.885	0.713	.031	1	view →
HNSC	OS	Tertile	IV	0.940	0.722	.024	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CINP–CCRCC (DFS)

Open the CCRCC breakdown →