CINP

Across TCGA patient cohorts, CINP mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CINP-associated genes across cancer lineages are Fibronectin, ATM, and eEF2. Each is linked with CINP in more than 1 cancer types. Because this analysis shows association rather than direction, both CINP-to-partner and partner-to-CINP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by CINP-low versus CINP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CINP→partner) and Y-score (partner→CINP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.401	-2.986	.020	.035	3	1
UCEC	ATM →	-0.555	-3.000	.019	.036	3	1
UCEC	eEF2 →	+0.421	+3.000	.024	.036	2	1
UCEC	c-Kit →	-0.272	-3.321	.026	.010	2	1
UCEC	Caspase-7-cleavedD198 →	+0.990	+3.321	.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Fibronectin by CINP expression — UCEC

Explore this box plot interactively →