CILP2

Across TCGA patient cohorts, CILP2 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CILP2-associated genes across cancer lineages are Notch1, FASN, and ERK2. Each is linked with CILP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CILP2-to-partner and partner-to-CILP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CILP2-low versus CILP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CILP2→partner) and Y-score (partner→CILP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.130	+1.687	.005	.013	3	3
SKCM	FASN →	-0.338	-1.807	.030	.024	3	2
UCEC	ERK2 →	+0.137	+2.700	.034	.005	3	2
COAD	Lck →	+0.357	+2.484	.007	.010	3	2
UCEC	p90 RSK →	+0.145	+1.495	.023	.034	3	2
UCEC	Rad50 →	-0.245	-1.874	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Notch1 by CILP2 expression — UCEC

Explore this box plot interactively →