CILP

Across TCGA patient cohorts, CILP mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CILP-associated genes across cancer lineages are 4E-BP1, ATM, and eIF4E. Each is linked with CILP in more than 3 cancer types. Because this analysis shows association rather than direction, both CILP-to-partner and partner-to-CILP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by CILP-low versus CILP-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CILP→partner) and Y-score (partner→CILP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	4E-BP1 →	+0.324	+2.824	.029	.036	3	4
UCEC	ATM →	-0.498	-1.584	<.001	.002	3	4
UCEC	eIF4E →	+0.163	+1.378	.009	.008	3	3
UCEC	PCNA →	+0.265	+1.807	<.001	<.001	3	3
UCEC	TIGAR →	+0.120	+1.211	.008	.014	3	3
UCEC	ASNS →	+0.395	+1.378	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

4E-BP1 by CILP expression — BLCA

Explore this box plot interactively →