CILK1

Across TCGA pan-cancer cohorts, CILK1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CILK1 data layer compared with 22 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher CILK1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CILK1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

THYM, UCEC, and BLCA are the cancer types where CILK1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
UCEC	DFS	Median	II,III,IV	1.000	0.300	.002	36	view →
BLCA	OS	Median	II,III,IV	1.000	0.596	.028	6	view →
LIHC	OS	Median	All	0.031	0.775	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CILK1–THYM (OS)

Open the THYM breakdown →