CILK1

Across TCGA patient cohorts, CILK1 mutation is significantly associated with the RNA expression of many other genes, with 3,171 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CILK1-associated genes across cancer lineages are SNRPA1, CRYBB2P1, and SPRYD7. Each is linked with CILK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CILK1-to-partner and partner-to-CILK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPA1 grouped by CILK1-low versus CILK1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CILK1→partner) and Y-score (partner→CILK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SNRPA1 →	+0.575	+3.331	.001	.005	3	3
UCEC	CRYBB2P1 →	+0.560	+2.136	<.001	<.001	3	3
UCEC	SPRYD7 →	+0.435	+2.115	<.001	<.001	3	3
STAD	RPS10-NUDT3 →	+0.165	+3.339	.006	.008	3	2
UCEC	EI24 →	+0.413	+2.432	.001	<.001	3	2
UCEC	CHEK1 →	+0.660	+3.108	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,171 associations by consensus.

SNRPA1 by CILK1 expression — SKCM

Explore this box plot interactively →