CILK1

Across TCGA patient cohorts, CILK1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CILK1-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, mTOR_pS2448, and Notch1. Each is linked with CILK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CILK1-to-partner and partner-to-CILK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by CILK1-low versus CILK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CILK1→partner) and Y-score (partner→CILK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.373	+1.331	.034	.043	3	2
UCEC	mTOR_pS2448 →	-0.144	-2.209	.005	.009	3	2
UCEC	Notch1 →	+0.177	+1.736	<.001	.007	3	2
UCEC	Shc_pY317 →	-0.213	-2.415	<.001	.003	3	2
UCEC	VHL →	-0.710	-1.847	.002	.007	3	2
UCEC	ATM →	-0.600	-3.687	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Acetyl-a-Tubulin-Lys40 by CILK1 expression — UCEC

Explore this box plot interactively →