CILK1

Across TCGA cell cohorts, CILK1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CILK1-associated genes across cancer lineages are SEL1L2, ELSPBP1, and KRTAP20-2. Each is linked with CILK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CILK1-to-partner and partner-to-CILK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEL1L2 grouped by CILK1-low versus CILK1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CILK1→partner) and Y-score (partner→CILK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SEL1L2 →	+0.016	+4.643	<.001	.005	3	1
OVARY	ELSPBP1 →	+0.140	+4.029	.005	.009	3	1
LUNG_NSCLC_LUAD	KRTAP20-2 →	+0.245	+4.887	<.001	.009	3	1
LARGE_INTESTINE	IAPP →	+0.535	+3.906	<.001	.005	3	1
LARGE_INTESTINE	GFRA4 →	+0.019	+3.345	.001	.007	3	1
LARGE_INTESTINE	MUC7 →	+0.093	+4.115	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

SEL1L2 by CILK1 expression — BLOOD_Lymphoma

Explore this box plot interactively →