CIDEA

Across TCGA patient cohorts, CIDEA mutation is significantly associated with the RNA expression of many other genes, with 466 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CIDEA-associated genes across cancer lineages are RIPOR1, RNA5SP277, and CHEK1. Each is linked with CIDEA in more than 1 cancer types. Because this analysis shows association rather than direction, both CIDEA-to-partner and partner-to-CIDEA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RIPOR1 grouped by CIDEA-low versus CIDEA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CIDEA→partner) and Y-score (partner→CIDEA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RIPOR1 →	+0.689	+3.467	<.001	.002	3	2
BLCA	RNA5SP277 →	+0.491	+5.038	<.001	.009	3	2
UCEC	CHEK1 →	+0.679	+2.243	.002	.006	3	1
UCEC	ADGRL3 →	+0.887	+2.608	.001	.006	3	1
UCEC	NCAPD3 →	+0.734	+2.917	<.001	.001	3	1
UCEC	GPATCH11 →	+0.519	+3.628	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 466 associations by consensus.

RIPOR1 by CIDEA expression — UCEC

Explore this box plot interactively →