CIDEA

Across TCGA patient cohorts, CIDEA mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CIDEA-associated genes across cancer lineages are MEK1, ER-alpha, and eIF4E. Each is linked with CIDEA in more than 1 cancer types. Because this analysis shows association rather than direction, both CIDEA-to-partner and partner-to-CIDEA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CIDEA-low versus CIDEA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CIDEA→partner) and Y-score (partner→CIDEA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.369	+2.000	.025	.032	3	2
COAD	ER-alpha →	+0.274	+2.815	.037	.036	3	1
UCEC	eIF4E →	+0.215	+3.169	.023	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.139	-2.321	.013	.033	3	1
UCEC	Notch1 →	+0.172	+2.700	.006	.006	3	1
UCEC	p27_pT198 →	+0.109	+2.000	.023	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

MEK1 by CIDEA expression — UCEC

Explore this box plot interactively →