Across TCGA pan-cancer cohorts, CICP24 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of CICP24’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where CICP24 RNA is repressed in tumor relative to normal tissue. In most cancer types CICP24 is over-expressed in tumor, although a few such as COAD and KIRC show the opposite, repressed pattern.
COAD and KIRC are the cancer types where CICP24 tumor–normal differential expression is most reproducible.