CIC

Across TCGA pan-cancer cohorts, CIC mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CIC data layer compared with 25 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CIC mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CIC expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

UCEC, CCRCC, and LUAD are the cancer types where CIC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.433	1.000	.007	36	view →
CCRCC	DFS	Median	IV	0.781	0.220	.017	18	view →
LUAD	OS	Median	All	0.840	0.651	.016	12	view →
HNSC	OS	Tertile	All	0.612	0.814	.023	5	view →
GBM	OS	Quartile	All	0.566	0.201	.024	3	view →
PDAC	OS	Quartile	All	0.939	0.670	.014	3	view →
LSCC	OS	Quartile	III,IV	0.589	0.893	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CIC–UCEC (OS)

Open the UCEC breakdown →