CIC

Across TCGA patient cohorts, CIC RNA expression is significantly associated with the protein abundance of many other proteins, with 9,102 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CIC-associated proteins across cancer lineages are PAFAH1B3, RBBP4, and KHDRBS1. Each is linked with CIC in more than 4 cancer types. Because this analysis shows association rather than direction, both CIC-to-partner and partner-to-CIC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CIC versus PAFAH1B3 in PDAC, with a Pearson correlation of 0.31.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CIC→partner) and Y-score (partner→CIC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PAFAH1B3 →	+0.399	+0.386	<.001	<.001	3	5
PDAC	RBBP4 →	+0.367	+0.366	<.001	.004	3	4
GBM	KHDRBS1 →	+0.266	+0.374	<.001	.002	3	4
LSCC	TMEM94_S1354 →	-0.510	-0.445	.002	.004	2	4
BRCA	PDGFRL →	+0.458	+0.439	.001	.004	3	3
CCRCC	MAST3_S847 →	-0.751	-0.508	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,102 associations by consensus.

CIC vs PAFAH1B3 — PDAC

Explore this scatter interactively →