CIC

Across TCGA patient cohorts, CIC protein abundance is significantly associated with the RNA expression of many other genes, with 9,794 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible CIC-associated genes across cancer lineages are NCAPH, FZD1, and FAM180A. Each is linked with CIC in more than 4 cancer types. Because this analysis shows association rather than direction, both CIC-to-partner and partner-to-CIC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CIC versus NCAPH in BRCA, with a Pearson correlation of -0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CIC→partner) and Y-score (partner→CIC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NCAPH →	-0.719	-0.145	<.001	.004	3	5
HNSC	FZD1 →	+0.980	+0.161	<.001	<.001	3	5
BRCA	FAM180A →	+0.653	+0.154	.001	.001	3	5
BRCA	PPIF →	-0.515	-0.194	.007	.002	3	5
LUAD	PRKD1 →	+0.751	+0.139	<.001	.001	3	5
LSCC	CENPA →	-0.879	-0.172	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,794 associations by consensus.

CIC vs NCAPH — BRCA

Explore this scatter interactively →