CIC

Across TCGA patient cohorts, CIC mutation is significantly associated with the total protein of many other genes, with 113 significant associations in total. COAD shows the largest number of these associations.

The most reproducible CIC-associated genes across cancer lineages are 4E-BP1, FASN, and YAP_pS127. Each is linked with CIC in more than 3 cancer types. Because this analysis shows association rather than direction, both CIC-to-partner and partner-to-CIC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by CIC-low versus CIC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CIC→partner) and Y-score (partner→CIC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.224	+1.857	.004	<.001	3	4
COAD	FASN →	+0.471	+1.708	.001	.026	3	3
COAD	YAP_pS127 →	-0.382	-2.584	<.001	.009	3	3
COAD	Bad_pS112 →	-0.193	-2.982	.010	.034	3	3
COAD	Cyclin-E2 →	+0.209	+3.321	.018	.009	3	3
COAD	Akt →	-0.762	-2.213	<.001	.010	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 113 associations by consensus.

4E-BP1 by CIC expression — UCEC

Explore this box plot interactively →