CIC

Across TCGA cell cohorts, CIC RNA expression is significantly associated with the go_rna of many other GO terms, with 4,737 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CIC-associated GO terms across cancer lineages are Positive regulation of cellular response to transforming growth factor beta stimulus, Positive regulation of transforming growth factor beta receptor signaling pathway, and Cytosolic transport. Each is linked with CIC in more than 16 cancer types. Because this analysis shows association rather than direction, both CIC-to-partner and partner-to-CIC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cellular response to transforming growth factor beta stimulus grouped by CIC-low versus CIC-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CIC→partner) and Y-score (partner→CIC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of cellular response to transforming growth factor beta stimulus →	+0.118	+1.059	<.001	<.001	3	17
SOFT_TISSUE	Positive regulation of transforming growth factor beta receptor signaling pathway →	+0.118	+1.059	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Cytosolic transport →	+0.079	+0.958	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Negative regulation of calcium ion export across plasma membrane →	+0.088	+0.866	<.001	<.001	3	16
STOMACH	Negative regulation of autophagy →	+0.082	+1.142	<.001	.001	3	16
STOMACH	Regulation of translational initiation →	+0.111	+1.608	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,737 associations by consensus.

Positive regulation of cellular response to transforming growth factor beta stimulus by CIC expression — SOFT_TISSUE

Explore this box plot interactively →