CIC

Across TCGA cell cohorts, CIC mutation is significantly associated with the RNA expression of many other genes, with 2,039 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CIC-associated genes across cancer lineages are HDDC2, LYG1, and SFT2D2. Each is linked with CIC in more than 2 cancer types. Because this analysis shows association rather than direction, both CIC-to-partner and partner-to-CIC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HDDC2 grouped by CIC-low versus CIC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CIC→partner) and Y-score (partner→CIC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HDDC2 →	+0.735	+2.545	<.001	<.001	3	3
LARGE_INTESTINE	LYG1 →	+1.025	+2.545	<.001	<.001	3	3
LARGE_INTESTINE	SFT2D2 →	+0.537	+1.714	<.001	.006	3	3
BLOOD_Leukemia	UBAP1L →	+0.516	+2.176	<.001	.001	3	3
OVARY	PAPOLB →	+0.007	+2.791	.006	.002	3	3
LARGE_INTESTINE	PIAS4 →	+0.638	+2.459	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,039 associations by consensus.

HDDC2 by CIC expression — LARGE_INTESTINE

Explore this box plot interactively →