CIB4

Across TCGA patient cohorts, CIB4 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CIB4-associated genes across cancer lineages are ACVRL1, Annexin_VII, and Shc_pY317. Each is linked with CIB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CIB4-to-partner and partner-to-CIB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACVRL1 grouped by CIB4-low versus CIB4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CIB4→partner) and Y-score (partner→CIB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACVRL1 →	-0.191	-3.000	.015	.037	2	2
UCEC	Annexin_VII →	-0.183	-3.000	.023	.037	3	1
UCEC	Shc_pY317 →	-0.183	-3.000	.037	.037	3	1
UCEC	Smad3 →	+0.234	+3.000	.007	.037	3	1
UCEC	BRD4 →	+0.408	+2.818	.012	.035	3	1
UCEC	Caspase-8 →	-0.320	-3.000	.027	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ACVRL1 by CIB4 expression — UCEC

Explore this box plot interactively →