CIAO2B

Across TCGA patient cohorts, CIAO2B mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CIAO2B-associated genes across cancer lineages are MIR378F, RNA5-8SP7, and RNU6-1015P. Each is linked with CIAO2B in more than 1 cancer types. Because this analysis shows association rather than direction, both CIAO2B-to-partner and partner-to-CIAO2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR378F grouped by CIAO2B-low versus CIAO2B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CIAO2B→partner) and Y-score (partner→CIAO2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR378F →	+0.488	+7.816	<.001	.008	3	1
BRCA	RNA5-8SP7 →	+0.237	+7.731	<.001	.009	3	1
BRCA	RNU6-1015P →	+0.341	+8.055	<.001	.007	3	1
BRCA	CLPTM1LP1 →	+0.189	+7.731	<.001	.009	3	1
BRCA	RNA5SP266 →	+0.323	+9.057	<.001	.003	3	1
BRCA	RNU6-284P →	+0.553	+8.471	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

MIR378F by CIAO2B expression — SKCM

Explore this box plot interactively →