CIAO2B

Across TCGA cell cohorts, CIAO2B RNA expression is significantly associated with the go_rna of many other GO terms, with 2,560 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CIAO2B-associated GO terms across cancer lineages are Vesicle uncoating, Peptidyl-methionine modification, and Protein depolymerization. Each is linked with CIAO2B in more than 9 cancer types. Because this analysis shows association rather than direction, both CIAO2B-to-partner and partner-to-CIAO2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vesicle uncoating grouped by CIAO2B-low versus CIAO2B-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CIAO2B→partner) and Y-score (partner→CIAO2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Vesicle uncoating →	+0.145	+0.860	.005	<.001	3	10
OESOPHAGUS	Peptidyl-methionine modification →	+0.164	+0.517	.004	.005	3	9
BONE	Protein depolymerization →	+0.126	+0.636	<.001	.002	2	10
CNS	Protein urmylation →	+0.031	+0.355	.008	.009	3	9
BONE	Regulation of establishment of protein localization to telomere →	+0.127	+0.718	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	7-methylguanosine cap hypermethylation →	+0.094	+0.712	.002	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,560 associations by consensus.

Vesicle uncoating by CIAO2B expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →