CIAO2A

Across TCGA pan-cancer cohorts, CIAO2A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CIAO2A data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CIAO2A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CIAO2A expression acts as an unfavorable survival marker.

LUAD, HNSC, and CCRCC are the cancer types where CIAO2A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.327	0.811	<.001	37	view →
HNSC	DFS	Quartile	II,III,IV	0.873	1.000	.005	21	view →
CCRCC	DFS	Median	IV	0.233	1.000	.008	18	view →
PDAC	DFS	Median	III,IV	0.465	0.903	.002	16	view →
LSCC	DFS	Median	III,IV	0.395	0.869	.001	10	view →
GBM	DFS	Tertile	All	0.607	0.772	.019	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CIAO2A–LUAD (OS)

Open the LUAD breakdown →