CIAO2A

Across TCGA patient cohorts, CIAO2A mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CIAO2A-associated genes across cancer lineages are EGFR_pY1068, Acetyl-a-Tubulin-Lys40, and JNK_pT183_Y185. Each is linked with CIAO2A in more than 1 cancer types. Because this analysis shows association rather than direction, both CIAO2A-to-partner and partner-to-CIAO2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CIAO2A-low versus CIAO2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CIAO2A→partner) and Y-score (partner→CIAO2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.279	-2.584	.017	.011	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.480	+3.700	.042	.001	3	1
UCEC	JNK_pT183_Y185 →	-0.225	-2.321	.004	.034	3	1
UCEC	Ku80 →	+0.240	+1.887	.029	.031	3	1
UCEC	mTOR_pS2448 →	-0.161	-3.150	.020	.019	3	1
UCEC	Myosin-IIa_pS1943 →	+0.240	+1.887	.012	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

EGFR_pY1068 by CIAO2A expression — UCEC

Explore this box plot interactively →