CIAO1

Across TCGA patient cohorts, CIAO1 protein abundance is significantly associated with the protein abundance of many other proteins, with 19,434 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible CIAO1-associated proteins across cancer lineages are NAP1L1, CCT2, and EIF3D. Each is linked with CIAO1 in more than 8 cancer types. Because this analysis shows association rather than direction, both CIAO1-to-partner and partner-to-CIAO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CIAO1 versus NAP1L1 in LSCC, with a Pearson correlation of 0.48.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CIAO1→partner) and Y-score (partner→CIAO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NAP1L1 →	+0.425	+0.237	<.001	<.001	3	8
PDAC	CCT2 →	+0.242	+0.212	<.001	<.001	3	7
OV	EIF3D →	+0.146	+0.128	.006	.008	1	9
PDAC	EIF3I →	+0.222	+0.197	<.001	<.001	3	7
UCEC	PSMA6 →	+0.237	+0.283	<.001	<.001	3	7
LUAD	MMS19 →	+0.229	+0.180	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,434 associations by consensus.

CIAO1 vs NAP1L1 — LSCC

Explore this scatter interactively →