CIAO1

Across TCGA patient cohorts, CIAO1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CIAO1-associated genes across cancer lineages are A-Raf_pS299, NF2, and 4E-BP1. Each is linked with CIAO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CIAO1-to-partner and partner-to-CIAO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by CIAO1-low versus CIAO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CIAO1→partner) and Y-score (partner→CIAO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.141	-2.321	.018	.035	3	1
UCEC	NF2 →	+0.229	+2.321	.035	.035	3	1
UCEC	4E-BP1 →	+0.304	+2.199	.025	.033	3	1
UCEC	Di-Ras3 →	-0.170	-2.321	.022	.035	3	1
UCEC	CDK1_pY15 →	+0.277	+2.829	.011	.035	2	1
UCEC	eIF4E →	+0.223	+2.321	.035	.035	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

A-Raf_pS299 by CIAO1 expression — UCEC

Explore this box plot interactively →