CIAO1

Across TCGA cell cohorts, CIAO1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,068 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CIAO1-associated GO terms across cancer lineages are Transcription initiation at RNA polymerase I promoter, DNA-templated transcription elongation, and Interstrand cross-link repair. Each is linked with CIAO1 in more than 16 cancer types. Because this analysis shows association rather than direction, both CIAO1-to-partner and partner-to-CIAO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription initiation at RNA polymerase I promoter grouped by CIAO1-low versus CIAO1-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CIAO1→partner) and Y-score (partner→CIAO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Transcription initiation at RNA polymerase I promoter →	+0.121	+0.466	.002	.001	3	17
OVARY	DNA-templated transcription elongation →	+0.083	+0.486	.002	<.001	3	14
LUNG_NSCLC_LUSC	Interstrand cross-link repair →	+0.087	+0.751	.008	.008	3	14
BONE	Metaphase/anaphase transition of cell cycle →	+0.173	+0.540	<.001	<.001	3	13
SOFT_TISSUE	Positive regulation of transcription by RNA polymerase I →	+0.124	+0.429	<.001	<.001	3	13
SOFT_TISSUE	Transcription by RNA polymerase I →	+0.097	+0.411	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,068 associations by consensus.

Transcription initiation at RNA polymerase I promoter by CIAO1 expression — LARGE_INTESTINE

Explore this box plot interactively →