CHURC1

Across TCGA pan-cancer cohorts, CHURC1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CHURC1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where CHURC1 RNA is repressed in tumor relative to normal tissue. In most cancer types CHURC1 is over-expressed in tumor, although a few such as BLCA and LUSC show the opposite, repressed pattern.

BLCA, LUSC, and KICH are the cancer types where CHURC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHURC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−1.004	.001	8	view →
LUSC	Female	All	−0.964	<.001	8	view →
KICH	Female	All	−1.368	<.001	7	view →
HNSC	Female	III,IV	+1.055	.003	7	view →
LUAD	Female	III,IV	−0.871	<.001	7	view →
UCEC	All	All	−1.213	<.001	6	view →
THCA	All	All	−0.385	<.001	6	view →
BRCA	All	All	−0.355	<.001	4	view →
COAD	All	All	−0.441	.001	3	view →
LIHC	All	All	+0.347	.004	3	view →
PRAD	All	All	−0.389	.002	2	view →
KIRP	Male	All	−0.388	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CHURC1–BLCA

Open the BLCA breakdown →