Across TCGA patient cohorts, CHUK protein abundance is significantly associated with the RNA expression of many other genes, with 6,311 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CHUK-associated genes across cancer lineages are BUB3, PI4K2A, and EXOSC1. Each is linked with CHUK in more than 5 cancer types. Because this analysis shows association rather than direction, both CHUK-to-partner and partner-to-CHUK results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHUK→partner) and Y-score (partner→CHUK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	BUB3 →	+0.558	+0.260	<.001	<.001	3	5
GBM	PI4K2A →	+0.478	+0.258	<.001	<.001	3	5
HNSC	EXOSC1 →	+0.387	+0.213	<.001	<.001	2	6
UCEC	KIFBP →	+0.508	+0.274	<.001	<.001	3	5
UCEC	HERC4 →	+0.383	+0.214	<.001	.005	3	4
GBM	VTI1A →	+0.387	+0.352	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,311 associations by consensus.

Exploration

CHUK survival (RNA) · tumor vs normal (RNA) · all CHUK data types