CHTOP

Across TCGA pan-cancer cohorts, CHTOP mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CHTOP data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CHTOP mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CHTOP expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

HNSC, UCEC, and CCRCC are the cancer types where CHTOP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.603	0.944	<.001	58	view →
UCEC	OS	Median	All	0.982	0.853	.012	22	view →
CCRCC	OS	Median	III,IV	0.133	0.989	.013	14	view →
GBM	OS	Tertile	All	0.670	0.331	.020	4	view →
PDAC	DFS	Median	III,IV	0.490	0.220	.032	2	view →
LSCC	DFS	Median	III,IV	0.868	1.000	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CHTOP–HNSC (DFS)

Open the HNSC breakdown →