CHTOP

Across TCGA patient cohorts, CHTOP protein abundance is significantly associated with the protein abundance of many other proteins, with 16,333 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible CHTOP-associated proteins across cancer lineages are RPL27A, RBM34, and RPL13. Each is linked with CHTOP in more than 8 cancer types. Because this analysis shows association rather than direction, both CHTOP-to-partner and partner-to-CHTOP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHTOP versus RPL27A in GBM, with a Pearson correlation of 0.47.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CHTOP→partner) and Y-score (partner→CHTOP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL27A →	+0.430	+0.525	<.001	<.001	3	9
BRCA	RBM34 →	+0.418	+0.447	<.001	<.001	3	9
BRCA	RPL13 →	+0.515	+0.631	<.001	<.001	3	8
BRCA	RPL13A →	+0.402	+0.585	<.001	<.001	3	8
BRCA	RPL4 →	+0.466	+0.483	<.001	<.001	3	8
UCEC	RPL6 →	+0.609	+0.419	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,333 associations by consensus.

CHTOP vs RPL27A — GBM

Explore this scatter interactively →