CHTOP

Across TCGA patient cohorts, CHTOP mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHTOP-associated genes across cancer lineages are Bim, Cyclin-B1, and EGFR. Each is linked with CHTOP in more than 1 cancer types. Because this analysis shows association rather than direction, both CHTOP-to-partner and partner-to-CHTOP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bim grouped by CHTOP-low versus CHTOP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHTOP→partner) and Y-score (partner→CHTOP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bim →	-0.255	-3.807	.031	<.001	3	2
UCEC	Cyclin-B1 →	+0.565	+2.000	.025	.032	3	2
UCEC	EGFR →	-0.169	-3.000	.019	.036	3	1
UCEC	Heregulin →	-0.172	-3.459	.001	.005	3	1
UCEC	Myosin-IIa →	+0.182	+2.184	.029	.033	3	1
UCEC	Akt_pT308 →	+0.664	+3.169	.019	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Bim by CHTOP expression — UCEC

Explore this box plot interactively →