CHTF18

Across TCGA patient cohorts, CHTF18 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHTF18-associated genes across cancer lineages are ERK2, MSH6, and Transglutaminase. Each is linked with CHTF18 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHTF18-to-partner and partner-to-CHTF18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by CHTF18-low versus CHTF18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHTF18→partner) and Y-score (partner→CHTF18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.173	+1.584	.012	.019	3	2
UCEC	MSH6 →	-0.434	-3.700	<.001	.001	3	2
UCEC	Transglutaminase →	+0.359	+1.925	.027	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.555	+2.321	.009	.033	3	2
UCEC	Cyclin-B1 →	+0.464	+1.700	.021	.042	3	2
UCEC	Di-Ras3 →	-0.169	-2.794	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

ERK2 by CHTF18 expression — UCEC

Explore this box plot interactively →