CHTF18

Across TCGA cell cohorts, CHTF18 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,597 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CHTF18-associated GO terms across cancer lineages are Positive regulation of DNA-directed DNA polymerase activity, Regulation of transcription of nucleolar large rRNA by RNA polymerase I, and Leading strand elongation. Each is linked with CHTF18 in more than 18 cancer types. Because this analysis shows association rather than direction, both CHTF18-to-partner and partner-to-CHTF18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA-directed DNA polymerase activity grouped by CHTF18-low versus CHTF18-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHTF18→partner) and Y-score (partner→CHTF18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of DNA-directed DNA polymerase activity →	+0.305	+2.190	<.001	<.001	3	19
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.156	+1.382	<.001	<.001	3	18
OESOPHAGUS	Leading strand elongation →	+0.189	+2.193	<.001	<.001	3	18
BONE	DNA integrity checkpoint signaling →	+0.100	+1.636	<.001	<.001	3	17
BONE	Mitotic DNA damage checkpoint signaling →	+0.133	+1.642	<.001	.007	2	18
UPPER_AERODIGESTIVE_TRACT	DNA replication proofreading →	+0.197	+1.453	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,597 associations by consensus.

Positive regulation of DNA-directed DNA polymerase activity by CHTF18 expression — BONE

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