CHSY1

Across TCGA pan-cancer cohorts, CHSY1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CHSY1 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher CHSY1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CHSY1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

PDAC, CCRCC, and HNSC are the cancer types where CHSY1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.230	0.666	.009	28	view →
CCRCC	OS	Median	III,IV	0.104	0.985	.024	10	view →
HNSC	DFS	Tertile	All	1.000	0.939	.018	6	view →
LSCC	DFS	Quartile	All	0.868	1.000	.029	5	view →
GBM	DFS	Tertile	All	0.242	0.443	.014	2	view →
LUAD	DFS	Quartile	III,IV	1.000	0.557	.016	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CHSY1–PDAC (DFS)

Open the PDAC breakdown →