CHSY1

Across TCGA patient cohorts, CHSY1 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHSY1-associated genes across cancer lineages are FoxM1, eIF4G, and FOXO3a_pS318_S321. Each is linked with CHSY1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHSY1-to-partner and partner-to-CHSY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by CHSY1-low versus CHSY1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHSY1→partner) and Y-score (partner→CHSY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	FoxM1 →	+0.294	+2.999	.016	.035	3	2
UCEC	eIF4G →	+0.320	+3.906	.002	<.001	3	2
UCEC	FOXO3a_pS318_S321 →	-0.106	-1.430	.012	.022	3	2
UCEC	GAPDH →	+0.395	+2.000	.030	.029	3	2
UCEC	Notch1 →	+0.140	+2.128	.003	.009	3	2
UCEC	Tuberin →	+0.356	+1.906	<.001	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

FoxM1 by CHSY1 expression — BLCA

Explore this box plot interactively →